Jan. 14, 2026
Most antipsychotic medications aren’t approved for the treatment of anxiety disorders, such as panic disorder and generalized anxiety disorder. Because antipsychotics can have adverse effects, we encourage prescribing providers to carefully assess symptoms, risks and benefits in prescribing medications for our members with anxiety disorders.
Our Behavioral Health Clinical Practice Guidelines have evidence-based information from nationally recognized sources. These are intended to provide a framework for patient care but not substitute for clinical judgment in individual cases. Following are guidelines related to anxiety disorder:
- Practice Guideline for the Treatment of Patients with Panic Disorder, Second Edition (2009) American Psychiatric Association
- Generalized Anxiety Disorder and Panic Disorder in Adults (2022) American Family Physician
- Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents with Anxiety Disorders (2020) American Academy of Child & Adolescent Psychiatry
- VA/DoD Clinical Practice Guideline for Management of Posttraumatic Stress Disorder and Acute Stress Disorder (2023) Department of Veterans Affairs/Department of Defense
For more information on medications in behavioral health care, see our Quick Reference on Potential Side Effects.
Closing care gaps: We track quality measures from the National Committee for Quality Assurance related to antipsychotic medications:
Diabetes Screening for People With Schizophrenia or Bipolar Disorder Who Are Using Antipsychotic Medications tracks the number of people 18 to 64 years old with schizophrenia or bipolar disorder who were dispensed an antipsychotic medication and had an annual diabetes screening.
Metabolic Monitoring for Children and Adolescents on Antipsychotics tracks the percentage of children and adolescents ages 1 to 17 years who had two or more antipsychotic prescriptions and had metabolic testing. Three rates are reported for children and adolescents on antipsychotics who received:
- Blood glucose testing
- Cholesterol testing
- Blood glucose and cholesterol testing
A higher rate represents more proper testing, which indicates better performance.
Resource for you: We created a resource for you on coding and documentation for Healthcare Effectiveness Data and Information Set® measures, called Quality Care. You can access it in Availity® Essentials in our payer space. Download it from the Resources section under Quality Improvement.
The above material is for informational purposes only and is not intended to be a substitute for the independent medical judgment of a physician. Physicians and other health care providers are encouraged to use their own best medical judgment based upon all available information and the condition of the patient in determining the best course of treatment. References to other third-party sources or organizations are not a representation, warranty, or endorsement of such organization. The fact that a service or treatment is described in this material is not a guarantee that the service or treatment is a covered benefit and members should refer to their certificate of coverage for more details, including benefits, limitations, and exclusions. Regardless of benefits, the final decision about any service or treatment is between the member and their health care provider.