Review Our Billing Guidelines for Laboratory Claims

Oct. 21, 2026

We encourage you to review the Ancillary Claim Submission information and follow the billing guidelines for independent clinical laboratory claims to ensure claims are processed efficiently and accurately. The guidelines are available in our Commercial Provider Manual.

Quick Tips and Reminders
Laboratory claims for Blue Cross and Blue Shield of Illinois members should be submitted through the plan state where the samples were collected.

Complete and legible laboratory medical records should be maintained and include the following information:  

• A signed valid requisition from the physician or qualified health care provider who is treating the patient and will use the results in the management of the patient’s specific medical problem
• Documentation of the services ordered
• Results of the services performed

For more information, refer to the Commercial Provider Manual or the BlueCard^® Program Provider Manual in Standards and Requirements.